PPARGC1A and Alzheimer disease: PGC-1α is a modulator of mitochondrial phenotype, its activity might be targeted through either PGC-1α activators, successfully tested in mouse models for other diseases (Lagouge et al., 2006; Dong et al., 2007), or agonists of the peroxisome proliferator-activated receptors (PPARs), which have demonstrated to attenuate mitochondrial dysfunction in AD mouse models (Nicolakakis et al., 2008; Johri et al., 2012).