FMR1 and psychiatric disorder: In contrast, a combination of whole exome and genome sequencing and CNV discovery in family and case-control samples has identified a number of genes disrupted by rare, damaging, de novo variants, and highlighted biology and function that resonates across psychiatric disorders, like RNAs regulated by Fragile X mental retardation 1 (FMRP) (Iossifov et al., 2012), synaptic scaffolding proteins, chromatin regulating machinery, and other genes related to overlapping neuropsychiatric disorders.