TAFRO syndrome describes a clinical subtype of idiopathic multicentric Castleman disease (iMCD) that is characterized by thrombocytopenia, anasarca, fever and/or elevated serum C-reactive protein, renal dysfunction or reticulin myelofibrosis, and organomegaly (hepatomegaly, splenomegaly, lymphadenopathy) (1, 2). The gene discussed is CRP; the disease is Castleman-Kojima disease.