Indeed, mice with loss function mutations in VEGF developed endotheliosis and “bloodless glomeruli,” and mice with overexpression of VEGF also had end-stage renal failure due to a collapsing glomerulopathy (capillary loops larger in diameter, multiple endothelial cell nuclei visible within and presence of mesangial cells in a crescent shape at the periphery of the glomerulus) (36). This evidence concerns the gene VEGFA and stage 5 chronic kidney disease.