CX3CR1−/− mice reconstituted with CX3CR1+CD11c+ DCs showed a diminished expression of cytokines (TNF-α, IL-6) and chemokines (CCL2, CCL3, CXCL1, and CXCL2) in the CNS during JE progression (Figure 10C). This evidence concerns the gene ITGAX and Japanese encephalitis.