The distinct functional phenotypes can be induced in vivo or in vitro by inducers either alone, or in combination, including IFN, immune complexes, helminth infections, LPS, complement components, apoptotic cells, macrophage colony stimulating factor (M-CSF), glucocorticoids, IL-4, IL-13, IL-10, and TGF-beta (35, 36). This evidence concerns the gene IL10 and helminthiasis.