CLDN8 and inflammatory bowel disease: Since claudin-8 acts as sealing claudins in junctional regions of normal epithelial surface as well as crypts(91) and prevents paracellular back-leakage of Na+ in colonic reabsorption(115), its reduction and redistribution from TJs to cytoplasm may lead to TJ structure disruption and increased epithelial permeability in IBD, especially in active CD.