Wnt/β-catenin signaling that participates in inflammation, cell differentiation and proliferation, seems to have a strong correlation with claudin-1, as claudin-1-overexpressing mice exhibit Wnt/β-catenin signaling activation, and caudal homeobox protein-2(Cdx-2)-associated Wnt signaling upregulates claudin-1 inversely in colorectal cancer cell lines (60, 64), along with combined upregulation of claudin-1 and β-catenin in human primary and metastatic colorectal cancer lesions (87). Here, CLDN1 is linked to metastatic colorectal cancer.