NR5A2 and colitis: The importance of LRH-1 in the regulation of intestinal GC synthesis and intestinal immune homeostasis has been demonstrated by the fact that LRH-1 haplodeficient mice and mice with intestine-specific deletion of LRH-1 exhibited strongly reduced GC synthesis, and consequently suffered from exacerbated colitis (87, 96, 138) (Figure 3).