TF and Tangier disease: In line with this, our study underlines the importance of using different clinical biomarkers (e.g., the ferritin plasma levels, the apo- and holo-transferrin ratio, the apo-heme concentration in erythrocytes, the mean corpuscular volume, etc.)for a proper assessment of iron deficiency—and thus anemia—before administering a therapy of iron supplementation that here we are speculating that could be associated to a chronic activation of macrophages, possibly explaining the already described risks of iron overload (48) and linked to inflammatory-related diseases (38–43, 49).