The levels of As-IgA and As-IgM were reported as elevated in some CPA cases (Kauffman et al., 1986), but previous studies were not very comprehensive and were characterized by very low sensitivity and specificity limiting their application (Schonheyder and Andersen, 1982; Weig et al., 2001; Du et al., 2012). Here, CD40LG is linked to congenital primary aphakia.