For example, GPL biosynthesis pathway were up-regulated in human hepatocarcinoma, cervical adenocarcinoma and embryonic kidney cells, while lysophosphatidic acid acyltransferase β (LPAATβ) and HIF1α were jointly overexpressed to improve cell viability under hypoxia (Triantafyllou et al., 2018). The gene discussed is IL31RA; the disease is cervical adenocarcinoma.