TARDBP and proteostasis deficiencies: •  Repetitive impact TBI leads to TDP-43 aggregation (34)•  A single impact injury causes TDP-43 pathology, including cleavage, phosphorylation, mislocalization, and cytoplasmic aggregation (30–33, 43, 54)•  This proteinopathy is exacerbated in transgenic mice (32, 54)