TARDBP and proteostasis deficiencies: •  Repetitive mild TBI leads to TDP-43 proteinopathy, including protein inclusions, cytoplasmic mislocalization, phosphorylation, and cleavage (12, 20, 32)•  A single TBI causes increased expression and intraneuronal inclusions of TDP-43 (52, 53)•  TBI is a risk factor for TDP-43 associated diseases with an odds ratio of 1.93 (50)