PLAT and Stroke: The 1995 National Institute of Neurological Disorders and Stroke rt-PA (recombinant tissue plasminogen activator) Stroke Study (NINDS trial) was a milestone for stroke therapy as it proved that treating ischemic stroke patients with rt-PA within 3 h of the onset of stroke symptoms results in a considerable neurological improvement at 3 months as compared to the placebo group without significant change in mortality (4).