NR3C1 and major depressive disorder: Although full exploration of the mechanism that underlies decreased GR expression in depression due to glucocorticoid resistance is still to come, the importance of GR expression as an independent signifier of glucocorticoid resistance is reinforced by the observation that GR expression levels did not correlate with the results of the DST in the population of depressed patients studied by Matsubara et al. (67).