In recent years, a numbers of lncRNAs [LncRNA uc.372 (Guo et al., 2018), SNHG16 (Wang et al., 2018), SNHG1 (Zhang et al., 2016), or MALAT1 (Liu et al., 2018)] were observed to negatively regulate miR-16 family member expression and played a role in pathogenesis of cancers. The gene discussed is SNHG1; the disease is cancer.