CASQ2 and cardiac arrhythmia: In another study, the Calsequestrin 2 (CASQ2) gene was delivered in CASQ2-knockout and CASQ2R33Q/+ mice mediated by AAV9 as a delivery mean to rescue their phenotype of Catecholaminergic Polymorphic Ventricular Tachycardia, an aggressive form of arrhythmia during exercise (Denegri et al., 2012, 2014).