TRPM4 and heart failure: Jacobs et al. (2015) studied the disease pattern of wild-type (WT) and Trpm4–/– mice after obstruction of the left anterior descending artery, resulting in severe ischemia of the cardiac muscle and heart failure. Here, Trpm4–/– mice showed improved survival, and the Trpm4–/– cardiac muscle showed increased contractility after ß-adrenergic stimulation.