HPS4 and Hermansky-Pudlak syndrome: Other genes coding for proteins involved in endocytosis were found in A. fraterculus, including HPS4 (Hermansky-Pudlak Syndrome 4), a factor involved in the regulation of the combination of late endosomes and RNA-processing GW bodies, FBX011 (F-box motif, Beta-helix motif), a regulator of endosome trafficking and the clathrin heavy chain (chc), which is needed for clathrin-mediated endocytosis (Swevers et al., 2013).