DUOX1 and bacterial infectious disease: The production of reactive oxygen species (ROS) and nitric oxide (NO), mediated by dual oxidase (Duox) and nitric oxide synthase (Nos) enzymes, respectively, constitutes an essential regulator of diverse biological processes that include the immune response against bacterial infection (Marletta, 1994; Kuraishi et al., 2013; Eleftherianos et al., 2014).