From that time until just a few years ago, the anti-TNF blockers (e.g., infliximab, adalimumab, certolizumab pegol, and golimumab) have been the only approved biologic drugs for the treatment of IBD, with the exception of natalizumab, which has been available only in the U.S., under specific restrictions due to its safety profile (Pagnini et al., 2017). The gene discussed is TNF; the disease is inflammatory bowel disease.