In nerve terminals, Synj1 participates to the control of synaptic vesicles retrieval (McPherson et al., 1996; Song and Zinsmaier, 2003; Mani et al., 2007) and cooperates with DNAJC6, another PD-causative gene (PARK19), in the process of clathrin disassembly from synaptic vesicles during endocytosis (Chang-Ileto et al., 2011; Edvardson et al., 2012). The gene discussed is SYNJ1; the disease is Parkinson disease.