TCAP acts in stress modulation, neuroprotection, CRF-induced cocaine addiction reinstatement, among other functions (Qian et al., 2004; Wang et al., 2005; Lovejoy et al., 2006; Al Chawaf et al., 2007a,b; Trubiani et al., 2007; Kupferschmidt et al., 2011; Tan et al., 2011; Chen et al., 2013; Erb et al., 2014; Colacci et al., 2015). Here, TCAP is linked to cocaine dependence.