TP53 and cancer: Studies focused on characterizing cancer cell lines by using reversed-phase protein arrays have shown that protein expression captured better the signals from genetic alterations than mRNA expression, and that correlations between patient cohorts and cell lines do exist (i.e., in terms of top mutated genes, mutation frequencies, and associated pathways such as p53, PI3K, NOTCH, and SWI/SNF complex signaling)17.