IL17C and chronic obstructive pulmonary disease: To study the function of IL-17C in the progression of Kras-induced cancer lesions in a model of COPD-like inflammation15,16, we crossed KrasG12D mice with Il-17c-deficient mice to obtain Kras mice deficient for IL-17C (Il-17c−/−/Kras mice) and exposed mice to NTHi three times a week for four or twelve weeks.