In addition to loss of large regions on chr1p, 3p, and 11q and a broad gain of chr17q, VCF2CNA found frequent focal amplifications of MYCN in NBL tumors and several potential cancer-related CNAs, including high-level amplifications of CDK4 (1 tumor), and ALK (2 tumors) (Fig. 6B). This evidence concerns the gene CDK4 and neoplasm.