To further understand the role of AS, we decided to test which genes showed a statistical expression correlation with different splicing factors expression included in the array, such as ESRP2, PRMT5, and RBM4. Using a PTM analysis, we found a high statistically significant correlation between the expression of these splicing genes and important cancer-related transcription factors (Fig. 1E–G), including genes involved in cancer (ETS1, XRN2, VDR), in epigenetic mechanisms (JARID1A, HOXC9), and once again MYC and E2F transcription factors. This evidence concerns the gene PRMT5 and cancer.