Gene Set Enrichment Analyses (GSEA), using TRANSFAC database and Chip Enrichment Analyses (ChEA), showed that those genes with AS presented binding sites for key cancer-related transcription factors (SMAD4, STAT3, RUNX1, TP53,...), epigenetic factors (JARID1A, KDM5B), and again E2Fs, and MYC (Fig. 4). The gene discussed is SMAD4; the disease is cancer.