In a previous work4, we already described that those patients with higher E2F3a expression suffered more and earlier recurrences, although the same relationship is not found for E2F1 and E2F2. This can be explained by the highly significant and positive correlation between E2F3a and EZH2, the core of the epigenetic Polycomb group expression, that mediates bladder tumor recurrence4. Here, EZH2 is linked to urinary bladder neoplasm.