TP53 and neoplasm: Using the RNAseq data from Hedegaard et al.’s study, where 476 NMIBC are included19, we could confirm that TP53 appeared more expressed in more advanced stages (Ta vs T1, p = 0.041), showing the same tendency for high-grade tumours (p = 0.059), and for MIBC tumours, although not reaching the statistical significance probably due to the few invasive samples included (16 T2-4 vs 457 Ta-T1).