SREBF2 and melanoma: To evaluate potential activators of DNFA expression, we depleted SREBF1, SREBF2, and co-activators MED15 and CREBBP28 with siRNAs, and examined DNFA expression across three melanoma cell lines: HT-144 (Fig. 2d,e), A375 (Supplementary Fig. 7i,j) and MEL-JUSO (Supplementary Fig. 8a,b).