EGFR inhibitors were used to treat those tumor-bearing mice and we observed that Erlo, Gefi and Lapa restrained the tumor growth and prolonged the tumor-bearing mice survival time in total and integrin αvβ3− A549 tumors while the mice bearing αvβ3+ A549 tumor revealed significant drug resistance (Figure 1I–K). This evidence concerns the gene EGFR and neoplasm.