Exogenous H2S also might protect mouse kidney against unilateral ureteral obstruction by suppressing ROS-AMPK-mediated autophagy, ameliorating blood-spinal cord barrier disruption and improving functional recovery by suppressing endoplasmic reticulum stress-mediated autophagy and inducing the apoptosis of hepatocellular carcinoma cells through promoting autophagy via the PI3K/AKT/mTOR signaling pathway (Chen et al., 2018a,b; Wang et al., 2017, 2018). The gene discussed is AKT1; the disease is hepatocellular carcinoma.