TLR4 and myocardial ischemia: Exogenous H2S can alleviate cardiac injury during acute myocardial ischemia by reducing inflammatory reaction in heart tissues under oxidative stress (Bai et al., 2018) and ameliorate LPS-induced diaphragm dysfunction in rats by reducing inflammation through ROS/MAPK and TLR4/NF-κB signaling pathways (Zhang et al., 2018).