AKT1 and myocardial ischemia: In recent years, it has been found that autophagy is closely related to the protective effect of H2S. Pretreatment with NaHS could alleviate acute myocardial ischemia injury by suppressing autophagy under oxidative stress, significantly reducing brain damage and preserving the blood-brain barrier integrity after traumatic brain injury by inhibiting autophagy via activation of the PI3K/Akt/mTOR signaling pathway and mitigating acrylonitrile-induced decrease of cell viability through influencing autophagy (Bai et al., 2018; Xu et al., 2018; Yang et al., 2018).