Lastly, while we have focused on monitoring CD8+ T cell responses to the immunodominant OVA epitope (OVA257–264; SIINFEKL), given that the prime/boost vaccine targets the full OVA antigen (in addition to OVA antigen released from IE9-mp1 cells), it is possible that CD8+ T cell responses specific for additional OVA epitopes, including the newly identified CD8+ T cell epitopes reported by Karandikar et al [65], are generated and may contribute to tumor attack. This evidence concerns the gene CD8A and neoplasm.