MiR-224 is deregulated expression in various cancers, including cervical cancer, ovarian cancer, and lung adenocarcinoma [82].MiR-224 is located in the gamma-aminobutyric acid (GABA), a receptor epsilon gene (GABRE) [83], and its expression is directly activated by E2F1through transactivation of the GABRE gene [84].P53 and p65 bind with miR-224 host gene and inactivate the GABAA receptor ε subunit promoter in ovarian cancer [85]. The gene discussed is TP53; the disease is ovarian cancer.