Recent whole-genome-wide sequencing studies of patient samples with myelodysplastic syndromes have revealed frequent somatic mutations in a key group of spliceosome-associated proteins, including Serine/arginine-rich splicing factor 2 (SRSF2) and Splicing factor U2AF 35 kDa subunit. This evidence concerns the gene SRSF2 and myelodysplastic syndrome.