In 2016, the revised World Health Organization (WHO) guidelines for tumours of haematopoietic and lymphoid tissues classified this type of tumour in a new category named high-grade B-cell lymphoma with rearrangements of MYC and BCL2 and/or BCL6, also called “double-hit” (DHL) or “triple-hit” lymphoma (THL) [9]. The gene discussed is BCL6; the disease is B-cell non-Hodgkin lymphoma.