Notably, the two strongest signatures were obtained for the two subgroups corresponding to Jurkat and H1437 cells with top marker genes consistent with previous knowledge: CD3G and CD3D, both of which are known T cell markers [40] being the top markers for Jurkat (T cell lymphoma), and TFF1 and BPIFA2, both shown to function in the respiratory tract [41, 42] being the top markers for H1437 (lung adenocarcinoma, epithelial/glandular cell type). Here, BPIFA2 is linked to lung adenocarcinoma.