That, in contrast to previously reported associations of poor glycemic control with lower ascendic aortic distensibility [36] and higher aortic pulse wave velocity in T2DM [37], systemic arterial compliance was unrelated to glycated hemoglobin in our diabetic AS subjects, might be due to multifactorial nature of vascular abnormalities in T2DM, including not only deposition of advanced glycation end-products, but also insulin resistance, impaired nitric oxide bioavailability, oxidative stress, enhanced fibrosis and inflammatory activation [11, 30]. The gene discussed is INS; the disease is aortic stenosis.