Therefore, alternative strategies to improve CV outcome are necessary in patients with combined AS and T2DM, in whom the risk of adverse CV events is elevated by 4- to sixfold in asymptomatic severe AS [1], renin-angiotensin antagonists are frequently underused, while surgical or transcatheter aortic valve implantation are limited to subjects with recognized indications to these procedures. Here, REN is linked to type 2 diabetes mellitus.