After adjusting age, sex, HTN, DM, serum albumin, EGFR, Ca, P, iPTH to the multiple regression analysis, only age (B = -2.3, P = 0.009), male (β =2.5,P = 0.018), serum albumin (β = − 0.20, P = 0.007) were found to be associated with 25(OH)D. The gene discussed is ALB; the disease is hypertensive disorder.