The convex area of the ascending aorta is more prone to aneurysmal development, most likely because of shear stress exposure, which is altered in BAV patients compared with individuals with TAV.32 Interestingly, we found that although no aortic aneurysms were present, the abundance of MFAP4 protein was higher in the convex area when analyzed by LC-MS/MS. This evidence concerns the gene MFAP4 and aortic aneurysm.