Interestingly, mutations in FBN1 causing MFS include those affecting PTMs of the protein, for example, the generation of an extra N-glycosylation site on FBN1.14 Aberrant glycosylation of proteins alters their folding, solubility, binding, and degradation.15 Interestingly, a large proportion of ECM proteins contain glycosylation sites, and the glycosylation profiles of FBN1 and other ECM constituents could, therefore, be relevant to the pathology of MFS. Here, FBN1 is linked to Marfan syndrome.