There are multiple animal and cell culture models of hypertrophy and HF confirming their role in these pathologies: knockout of Trpc genes or use of TRPC inhibitors prevents hypertrophy and HF development, and their increased expressions was detected after neuroendocrine agonist infusion (e.g., endothelin-1, phenylephrine and angiotensin II) and/or pressure overload stimulation [13,14]. The gene discussed is EDN1; the disease is hydrops fetalis.