LCK and acute lymphoblastic leukemia: It is possible that Lck plays a role in the assembly of the BLNK/Btk/Grb2 signalosome, which is required for the activation of PLCγ2 (indeed Lck regulates PLCγ2 in acute lymphoblastic leukemia, see below) or that Lck regulates PLCγ2 activation via alternative aberrant pathways.