Using Ba/F3 cells lacking endogenous Lck as a murine model for AML, it was shown that ectopic expression of Lck significantly enhanced the colony forming capacity of the FLT3-ITD mutant, but it had no effect on the survival or apoptosis of Ba/F3 cells transfected with FLT3 WT. The gene discussed is FLT3; the disease is acute myeloid leukemia.