It is possible that Lck plays a role in the assembly of the BLNK/Btk/Grb2 signalosome, which is required for the activation of PLCγ2 (indeed Lck regulates PLCγ2 in acute lymphoblastic leukemia, see below) or that Lck regulates PLCγ2 activation via alternative aberrant pathways. This evidence concerns the gene PLCG2 and acute lymphoblastic leukemia.