Thus, it is possible that the combined Th2/Th1 balanced immunity that was developed in the WIV N3+FliC groups provided a lasting protective immune mixture containing not only a cell-mediated IFN-gamma immunity against conserved NP-epitopes and mucosal broadly HA-binding IgA, but also serum IgG with influenza-specific ADCC-activity, often requiring antibodies with high binding affinity. Here, IFNG is linked to influenza.