ADORA2A and Cognitive impairment: CBD blunted the cognitive impairment induced by THC in an adenosine A2A receptor-dependent manner [113] and abolished the memory impairment in the object recognition task induced by nicotine withdrawal (precipitated by the administration of the nicotinic antagonist mecamylamine) as well as the neuroinflammatory response and the impairment in neurogenesis associated with these cognitive deficits (as previously commented) [100].