AKT1 and central nervous system cancer: Oleuropein [63,65,69], oleocanthal [21,66,67,68,71] and hydroxytyrosol [72] were observed to cause downregulation of p-AKT in prostate cell lines, glioma cell lines, hepatic steatosis models, liver and colon cancer, non-melanoma skin cancer, myeloma-derived cell lines and human malignant melanoma cells.