KNG1 and type 2 diabetes mellitus: We have previously reported that addition of a threshold concentration of SKA-31 (0.3 μM) to the coronary perfusate enhanced primary vasodilatory responses to BK in Langendorff-perfused hearts from Wistar and type 2 diabetic Goto-Kakizaki rats, suggesting that SKA-31 treatment could boost endothelial function, even under conditions of type 2 diabetes [28].