Similar to depletion of C/EBPβ, inhibition of δ-secretase activity by the C189S mutant also restored dendritic spines and synapse density, resulting in alleviation of LTP impairments and cognitive deficits induced by BDNF depletion in the hippocampus (Figures S7J–S7Q). Here, BDNF is linked to Cognitive impairment.