In addition to promoting the production of inflammatory mediators, C/EBP family members are themselves induced by the classical pro-inflammatory triad of IL-1 β (interleukin-1 β), IL-6, and tumor necrosis factor alpha (TNF-α) (Künzi and Pitha, 1996; Magalini et al., 1995; Poli, 1998; Wedel and Ziegler-Heitbrock, 1995), all of which are significantly increased in pathologically impacted regions of the AD brain (Akiyama et al., 2000). The gene discussed is TNF; the disease is Alzheimer disease.