In 2009, Singh et al. (10) reported that Ca2+/calmodulin-dependent kinase II (CaMKII)-induced activation of NF-κB pathway triggered CFB expression in a mouse model of myocardial infarction, suggesting that CaMKII functions as a link between inflammation and CH (10,11). This evidence concerns the gene NFKB1 and cyclic hematopoiesis.