Inclusion of NT-proBNP to simple LVESd-based risk stratification (when only patients with simultaneous change in LVESd >-12.3% and NT-proBNP >1230 ng/L were considered high-risk) resulted in net reclassification improvement of 10.8%, 14.2%, 13.5%, and 11.5% for HF hospitalization, HF death, cardiac death, and all-cause death, respectively. The gene discussed is NPPB; the disease is hydrops fetalis.