For example, although RAC1 is generally thought to play a tumor‐promoting role in tumor development (Baugher et al., 2005; Chen et al., 2011; Frances et al., 2015), some research indicates that RAC1 suppresses tumor progression in renal carcinomas and skin cancers (Engers et al., 2001; Malliri et al., 2002). Here, RAC1 is linked to renal carcinoma.