Proximal tubule‐specific insulin‐resistant‐knockout mice show hyperglycemia through increased gluconeogenesis (Tiwari et al., 2013), whereas podocyte‐specific insulin‐resistant‐knockout mice show losses of podocyte foot processes and cytoskeletal architecture and develop significant albuminuria under normoglycemic conditions (Welsh et al., 2010). The gene discussed is INS; the disease is Hyperglycemia.