PGC‐1α is decreased in various models of CKD, including unilateral ureteral obstruction‐induced fibrosis (Han et al., 2017), db/db diabetic mice (Hong et al., 2014; Kim, Lee, et al., 2013; Kim, Lim, et al. 2013; Long et al., 2016; Yuan et al., 2018; Zhang, Liu, Zhou, Wang, & Chen, 2018), and streptozotocin‐induced diabetic mice (Kwon et al., 2017). Here, PPARGC1A is linked to chronic kidney disease.