PKM and Hyperglycemia: A recent study demonstrated that the podocyte‐specific deletion of PKM2 accelerated albuminuria in streptozotocin‐induced diabetic mice and that TEPP‐46, a small molecule PKM2 activator, reversed hyperglycemia‐induced elevation in toxic glucose metabolites and mitochondrial dysfunction by increasing the PGC‐1α level (Qi et al., 2017).