Alternatively, POPs‐generated and T2DM‐mediated oxidative stressors may be compensated for by SOD‐1 and SOD‐2 protein levels; however, in ob/ob‐POPs mice reduced SOD‐1 and SOD‐2 may not be able to offset rising ROS levels due to POPs exposure. This evidence concerns the gene SOD1 and type 2 diabetes mellitus.