In states of metabolic dysfunction such as obesity and diabetes, ROS levels become exceedingly high, and when compounded with POPs exposure, innate antioxidant defense mechanisms become overwhelmed with increased levels of ROS from the activation of RAGE/NF‐κB signaling.24, 26 The following results demonstrate a potential role for AGE‐RAGE signaling in the POPs‐mediated remodeling. The gene discussed is NFKB1; the disease is Obesity.