Since POPs exposure has been positively correlated with hyperglycemia and T2DM, and T2DM complications, including cardiac remodeling as indicated by left ventricular function and/or hypertrophy as described in previous studies, we aimed to determine the role of POPs exposure and the potential mechanisms responsible for increased incidence of maladaptive responses resulting from AGE‐RAGE signaling.7, 10, 36. This evidence concerns the gene RENBP and hypertrophy.