NFKB1 and obesity due to melanocortin 4 receptor deficiency: In states of metabolic dysfunction such as obesity and diabetes, ROS levels become exceedingly high, and when compounded with POPs exposure, innate antioxidant defense mechanisms become overwhelmed with increased levels of ROS from the activation of RAGE/NF‐κB signaling.24, 26 The following results demonstrate a potential role for AGE‐RAGE signaling in the POPs‐mediated remodeling.