Although it is well documented that downregulation of Hsp90 leads to degradation of mutant p53 in cancer (Brosh & Rotter, 2009; Taipale et al., 2010), Western blot analysis demonstrated that depletion of Hsp90β, but not Hsp90α, significantly enhanced the expression of p53 in myoblasts (Figure 1i). This evidence concerns the gene TP53 and cancer.