Cushing’s disease (CD), or pituitary-dependent Cushing’s syndrome (CS), is caused by an adrenocorticotrophic hormone (ACTH)-secreting pituitary tumor, leading to chronic hypercortisolism, which results in a typical clinical picture; this is characterized by weight gain with moon face, facial plethora, buffalo hump, supraclavicular and dorsal fat pads, cutaneous purplish striae, bruising, proximal myopathy, and hirsutism and/or acne [1–5]. Here, POMC is linked to pituitary tumor.