In the multivariate analysis, the expression of GPx4 (log-transformed) remained lower in placentas of the group of women with prepregnancy obesity (ß = -0.08, p = 0.03) after adjusting for gestational age (ß = -0.08, p = 0.001) and magnesium average intake (ß = 0.03, p = 0.04) than in the group of normal weight (R2 = 0.38). The gene discussed is GPX4; the disease is obesity due to melanocortin 4 receptor deficiency.